ARTIGOS

Você está em - Home - Artigos - Pedras nos rins: uma hipótese de origem fetal.

Pedras nos rins: uma hipótese de origem fetal.



Kidney stones are common with a multifactorial aetiology involving dietary, environmental and genetic factors. In addition, patients with nephrolithiasis are at greater risk of hypertension, diabetes, metabolic syndrome, and osteoporosis although the basis for this is not fully understood. All of these renal stone associated conditions have also been linked with adverse early life events, including low birth weight, and it has been suggested that this developmental effect is due to excess exposure to maternal glucocorticoids in utero. This is proposed to result in long-term increased hypothalamic-pituitary-axis activation and there are mechanisms through which this effect could also promote urinary lithogenic potential. We therefore hypothesise that the association between renal stone disease and hypertension, diabetes, metabolic syndrome and osteoporosis may be related by a common pathway of programming in early life which, if validated, would implicate the developmental origins hypothesis in the aetiology of nephrolithiasis.

Fonte: http://www.ncbi.nlm.nih.gov/pubmed/23703881

VEJA TAMBÉM:



Texto Original



Kidney stones are common with a multifactorial aetiology involving dietary, environmental and genetic factors. In addition, patients with nephrolithiasis are at greater risk of hypertension, diabetes, metabolic syndrome, and osteoporosis although the basis for this is not fully understood. All of these renal stone associated conditions have also been linked with adverse early life events, including low birth weight, and it has been suggested that this developmental effect is due to excess exposure to maternal glucocorticoids in utero. This is proposed to result in long-term increased hypothalamic-pituitary-axis activation and there are mechanisms through which this effect could also promote urinary lithogenic potential. We therefore hypothesise that the association between renal stone disease and hypertension, diabetes, metabolic syndrome and osteoporosis may be related by a common pathway of programming in early life which, if validated, would implicate the developmental origins hypothesis in the aetiology of nephrolithiasis.

VEJA TAMBÉM: